CENTELLA ASIATICA EXTRACT EFFECT ON POSTOPERATIVE WOUND HEALING

##plugins.themes.academic_pro.article.sidebar##

Published Dec 10, 2021
https://doi.org/10.55116/IJIM.V1I1.28
Download
PDF
Statistic
Vol. 2 No. 2 (2021): International Journal Islamic Medicine

##plugins.themes.academic_pro.article.main##

Elza Iskandar
Universitas Sriwijaya
Theodorus Theodorus
Universitas Sriwijaya
Anang Tribowo
Universitas Sriwijaya
Riani Erna
Fatimah Syakirah
Universitas Sriwijaya

Abstract

Wound healing is a complex process that is divided into four phases, namely the hemostasis, inflammation, proliferation, and tissue remodeling phase. Centella asiatica is a widely used and very popular traditional plant in the field of health for a long time. Various in vitro and in vivo studies have proven the efficacy of Centella asiatica extract in the wound healing process. This literature review uses literature search methods from Pubmed, Science Direct, and Cochrane Library with keywords Centella asiatica, wound healing, surgery. This study aims to study the effects of Centella asiatica extract on postoperative wound healing.

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

How to Cite
1.
Iskandar E, Theodorus T, Tribowo A, Erna R, Syakirah F. CENTELLA ASIATICA EXTRACT EFFECT ON POSTOPERATIVE WOUND HEALING. International J. of Islamic and Complementary Medicine [Internet]. 2021 Dec. 10 [cited 2024 May 9];2(2):47-58. Available from: https://islamicmedicine.or.id/index.php/ijim/article/view/28

References

  1. Okur ME, Karantas ID, Şenyiğit Z, Üstündağ Okur N, Siafaka PI. Recent trends on wound management: New therapeutic choices based on polymeric carriers. Asian Journal of Pharmaceutical Sciences. 2020 Nov 1;15(6):661–84.
  2. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes: Cellular Mechanisms of Wound Repair. Open Biology. 2020 Sep 1;10(9).
  3. Harper D, Young A, McNaught CE. The physiology of wound healing. Surgery (United Kingdom). 2014 Jul 24;32(9):445–50.
  4. Vercelli S, Ferriero G, Sartorio F, Stissi V, Franchignoni F. How to assess postsurgical scars: A review of outcome measures. Disability and Rehabilitation. 2003 Jan 1;25(31):2055–63.
  5. Hintschich C. Periokuläre plastische chirurgie. Deutsches Arzteblatt. 2010 Mar 5;107(9):141–6.
  6. Oestreicher J, Mehta S. Complications of Blepharoplasty: Prevention and Management. Plastic Surgery International. 2012;2012:1–10.
  7. Jenwitheesuk K, Rojsanga P, Chowchuen B, Surakunprapha P. A prospective randomized, controlled, double-blind trial of the efficacy using centella cream for scar improvement. Evidence-based Complementary and Alternative Medicine. 2018;2018.
  8. Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatologii i Alergologii. 2013;30(1):46–9.
  9. Tsioufis C, Bafakis I, Kasiakogias A, Stefanadis C. The role of matrix metalloproteinases in diabetes mellitus. Current Topics in Medicinal Chemistry. 2012;12(10):1159–65.
  10. Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: Pathophysiology, classification, and treatment. Dermatologic Surgery. 2016;2017(43):3–18.
  11. Soomboonwong J. Chinese Herbs and Herbal Medicine. Duke BL, editor. Chinese Herbs and Herbal Medicine. New York: Nova Science Publisher, Inc.; 2015. 48–62.
  12. Singh S, Gautam A, Sharma A, Batra A. CENTELLA ASIATICA (L.): A PLANT WITH IMMENSE MEDICINAL POTENTIAL BUT THREATENED. International Journal of Pharmaceutical Sciences Review and Research. 2010;4(2):9–17.
  13. Calapai Gioacchino. Assessment report on Centella asiatica (L.) Urban, herba [Internet]. London; 2010 Nov. Available from: www.ema.europa.eu
  14. Sutardi S. Kandungan Bahan Aktif Tanaman Pegagan dan Khasiatnya untuk Meningkatkan Sistem Imun Tubuh. Jurnal Penelitian dan Pengembangan Pertanian. 2017 Jan 23;35(3):121.
  15. Randriamampionona D, Diallo B, Rakotoniriana F, Rabemanantsoa C, Cheuk K, Corbisier AM, et al. Comparative analysis of active constituents in Centella asiatica samples from Madagascar: Application for ex situ conservation and clonal propagation. Fitoterapia. 2007 Dec;78(7–8):482–9.
  16. Wu F, Bian D, Xia Y, Gong Z, Tan Q, Chen J, et al. Identification of major active ingredients responsible for burn wound healing of Centella asiatica herbs. Evidence-based Complementary and Alternative Medicine. 2012;2012.
  17. Cotellese R, Hu S, Belcaro G, Ledda A, Feragalli B, Dugall M, et al. Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids. Minerva chirurgica. 2018 Nov;73:151–6.
  18. Ago M, Adifa D N,. Benefits of Gotu Kola Leaf in Responding to Prevent the Form of Keloid in The Wound. Indonesian Journal of Global Health Research. 2020 Feb 1;2(1):23–8.
  19. Abdul Hamid A, Md Shah Z, Muse R, Mohamed S. Characterisation of antioxidative activities of various extracts of Centella asiatica (L) Urban. Food Chemistry. 2002;465–9.
  20. Tang B, Zhu B, Liang Y, Bi L, Hu Z, Chen B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. Archives of Dermatological Research. 2011 Oct;303(8):563–72.
  21. Chuangsuwanich A, Arunakul S, Kamnerdnakta S. The efficacy of combined herbal extracts gel in reducing scar development at a split-thickness skin graft donor site. Aesthetic Plastic Surgery. 2013 Aug;37(4):770–7.
  22. Gao X, Lin J, Sun L. Clinical effects of Dermatix Ultra silica gel and asiaticoside cream on hyperplastic scar tissue in patients after epicanthoplasty. Chinese Journal of Medical Aesthetics and Cosmetology. 2019 Dec 15;25:508–11.
  23. Pratami E, Isfentiani D. Centella asiatica EXTRACT REDUCES PAIN AND ENHANCES EPISIOTOMY WOUND HEALING. In: International Conference On Health Polytechnic Surabaya. Surabaya; 2016. p. 243–8.
  24. Chiaretti M, Fegatelli DA, Pappalardo G, Venti MDS, Chiaretti AI. Comparison of Centella with Flavonoids for Treatment of Symptoms in Hemorrhoidal Disease and After Surgical Intervention: A Randomized Clinical Trial. Scientific Reports. 2020 Dec 1;10(1).
  25. Damkerngsuntorn W, Rerknimitr P, Panchaprateep R, Tangkijngamvong N, Kumtornrut C, Kerr SJ, et al. The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Alternative and Complementary Medicine. 2020 Jun 1;26(6):529–36.
  26. Kang MS, Park KC, Nam SM. A split-face study of moisturizer containing Centella asiatica extract after ablative fractional carbon dioxide laser resurfacing. Archives of Aesthetic Plastic Surgery. 2021 Apr 30;27(2):56–60.
  27. Surakunprapha P, Winaikosol K, Chowchuen B, Jenwitheesuk K, Jenwitheesuk K. Adding Herbal Extracts to Silicone Gel on Post-Sternotomy Scar: A Prospective Randomised Double-Blind Study. Journal of Wound Care. 2020;29:36–42.
  28. Jenwitheesuk K, Surakunprapha P, Jenwitheesuk K, Kuptarnond C, Prathanee S, Intanoo W. Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: A prospective randomized, double blinded, controlled trial. International Wound Journal. 2012 Aug;9(4):397–402.
  29. Surakunprapha P, Winaikosol K, Chowchuen B, Punyavong P, Jenwitheesuk K, Jenwitheesuk K. A Prospective Randomized Double-blind study of silicone gel plus Herbal Extracts Versus Placebo in Pre-sternal hypertrophic scar prevention and amelioration. Heliyon. 2020 May 1;6(5).
  30. Chuangsuwanich A, Jongjamfa K. The Efficacy of Combined Herbal Extracts Gel Preparation in the Prevention of Postsurgical Hypertrophic Scar Formation. Dermatology and Therapy. 2014 Dec 1;4(2).
  31. Kircik LH. Comparative Study of the Efficacy and Tolerability of a Unique Topical Scar Product vs White Petrolatum Following Shave Biopsies. J Drugs Dermatol. 2013;12(1):86–90.
  32. Romo EM, Fundora FP, Albajes CR, Esteris López L, Hana Z. The effectiveness of cream with Centella Asiatica and Pinus Sylvestris to treat scars and burns. Clinical trail. Dermatologia Kliniczna. 2012;14(2):105–10.