EFFECT OF MONDAY THURSDAY FASTING ON WORKING MEMORY AFTER ACUTE STRESS EXPOSURE

##plugins.themes.academic_pro.article.main##

Abdullah Faqih
Sinu Andhi Jusup
Nanang Wiyono
Isna Qadrijati

Abstract

Working memory is part of cognitive function relates to the learning process and associates human behavior with the nervous system. Stress can cause a disruption to the body's homeostasis system. Monday-Thursday fasting can be used to counter the negative effects of stress by inhibiting stress mediators pathways. This study aims to prove that monday-thursday fasting can maintain working memory function after getting acute stress.  This study was quasi experimental with post test only control group design in 124 medical  students of  Sebelas Maret University, aged 18-25 years, normal BMI, and not taking corticosteroid or psychopharmaceutical drugs. Samples were taken by purposive sampling method divided into 4 groups. The control did not get treatment, treatment group 1 (TG1) was given acute stress induction in the form of academic examinations, sing a song stress test (SSST), and arithmetic test, treatment group 2 (TG2) carried out fasting at least 3 months and was given acute stress induction. Dependent variables are Monday-thursday fasting and acute stressors in the form of nominal categorical data. Independent variables in the form of working memory measured using digit-span tests in the form of numerical-interval data. Measurements of working memory were carried out simultaneously in the tutorial room after each group received treatment. Working memory data were analyzed by MANOVA and Bonferroni tests (a = 0.05).


The highest working memory is found in TG2 followed by control, and TG1. The results of the MANOVA test showed significant differences between the four groups with p = 0,000. The Bonferroni test results show significant differences between the control-TG1 and TG1-TG2 with each p <0.05. Fasting on Mondays-Thursdays activity can maintain a working memory function when the body gets acute stress.

##plugins.themes.academic_pro.article.details##

How to Cite
1.
Faqih A, Jusup SA, Wiyono N, Qadrijati I. EFFECT OF MONDAY THURSDAY FASTING ON WORKING MEMORY AFTER ACUTE STRESS EXPOSURE. International J. of Islamic and Complementary Medicine [Internet]. 2023 Sep. 20 [cited 2024 May 17];4(2):71-8. Available from: https://islamicmedicine.or.id/index.php/ijim/article/view/54

References

  1. Gagnon SA, Wagner AD. Acute stress and episodic memory retrieval: Neurobiological mechanisms and behavioral consequences. Annals of the New York Academy of Sciences. 2016;1369(1):55–75. doi:10.1111/nyas.12996
  2. Lovallo WR, Robinson JL, Glahn DC, Fox PT. Acute effects of hydrocortisone on the human brain: An fmri study. Psychoneuroendocrinology. 2010;35(1):15–20. doi:10.1016/j.psyneuen.2009.09.010
  3. Cheng G, Huang C, Deng H, Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: A meta-analysis of longitudinal studies. Internal Medicine Journal. 2012;42(5):484–91. doi:10.1111/j.1445-5994.2012.02758.x
  4. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Research Reviews. 2017;39:46–58. doi:10.1016/j.arr.2016.10.005
  5. Kelly KA, Miller DB, Bowyer JF, O’Callaghan JP. Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. Journal of Neurochemistry. 2012;122(5):995–1009. doi:10.1111/j.1471-4159.2012.07864.x
  6. Moro T, Tinsley G, Bianco A, Marcolin G, Pacelli QF, Battaglia G, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. Journal of Translational Medicine. 2016;14(1). doi:10.1186/s12967-016-1044-0
  7. Azevedo FR, Ikeoka D, Caramelli B. Effects of intermittent fasting on metabolism in men. Revista da Associação Médica Brasileira. 2013;59(2):167–73. doi:10.1016/j.ramb.2012.09.003
  8. Australian Psychology Society. (2017). Symptom of Stress. Sydney.
  9. Marks WN, Fenton EY, Guskjolen AJ, Kalynchuk LE. The effect of chronic corticosterone on fear learning and memory depends on dose and the testing protocol. Neuroscience. 2015;289:324–33. doi:10.1016/j.neuroscience.2015.01.011
  10. Hadem IK, Majaw T, Kharbuli B, Sharma R. Beneficial effects of dietary restriction in Aging Brain. Journal of Chemical Neuroanatomy. 2019;95:123–33. doi:10.1016/j.jchemneu.2017.10.001
  11. Pruessner JC, Dedovic K, Pruessner M, Lord C, Buss C, Collins L, et al. Stress regulation in the central nervous system: Evidence from structural and functional neuroimaging studies in human populations - 2008 curt richter award winner. Psychoneuroendocrinology. 2010;35(1):179–91. doi:10.1016/j.psyneuen.2009.02.016
  12. Silva WCN, Köhler CC, Radiske A, Cammarota M. D1/D5 dopamine receptors modulate spatial memory formation. Neurobiology of Learning and Memory. 2012;97(2):271–5. doi:10.1016/j.nlm.2012.01.005
  13. Longo VD, Mattson MP. Fasting: Molecular mechanisms and clinical applications. Cell Metabolism. 2014;19(2):181–92. doi:10.1016/j.cmet.2013.12.008
  14. Park HR, Lee J. Neurogenic contributions made by dietary regulation to hippocampal neurogenesis. Annals of the New York Academy of Sciences. 2011;1229(1):23–8. doi:10.1111/j.1749-6632.2011.06089.x
  15. Beste C, Schneider D, Epplen JT, Arning L. The functional BDNF VAL66MET polymorphism affects functions of pre-attentive visual sensory memory processes. Neuropharmacology. 2011;60(2–3):467–71. doi:10.1016/j.neuropharm.2010.10.028
  16. Donzis EJ, Tronson NC. Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences. Neurobiology of Learning and Memory. 2014;115:68–77. doi:10.1016/j.nlm.2014.08.008
  17. Zhao H, Alam A, San C-Y, Eguchi S, Chen Q, Lian Q, et al. Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments. Brain Research. 2017;1665:1–21. doi:10.1016/j.brainres.2017.03.029
  18. Christiansen AM, Herman JP, Ulrich-Lai YM. Regulatory interactions of stress and reward on rat forebrain opioidergic and GABAergic circuitry. Stress. 2011;14(2):205–15. doi:10.3109/10253890.2010.531331
  19. Corbett B, Weinberg L, Duarte A. The effect of mild acute stress during memory consolidation on emotional recognition memory. Neurobiology of Learning and Memory. 2017;145:34–44. doi:10.1016/j.nlm.2017.08.005
  20. Li L, Wang Z, Zuo Z. Chronic intermittent fasting improves cognitive functions and brain structures in mice. PLoS ONE. 2013;8(6). doi:10.1371/journal.pone.0066069
  21. Shojaie M, Ghanbari F, Shojaie N. Intermittent fasting could ameliorate cognitive function against distress by regulation of inflammatory response pathway. Journal of Advanced Research. 2017;8(6):697–701. doi:10.1016/j.jare.2017.09.002
  22. Vasconcelos AR, Yshii LM, Viel TA, Buck HS, Mattson MP, Scavone C, et al. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. Journal of Neuroinflammation. 2014;11(1). doi:10.1186/1742-2094-11-85