THE POTENTIAL OF GINGEROL ACTIVE COMPOUNDS IN ZINGIBER OFFICINALE AS ANTI-CANCER AGENTS

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Published Oct 1, 2024
https://doi.org/10.55116/IJICM.V5I2.83
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Vol. 5 No. 2 (2024): International Journal of Islamic and Complementary Medicine

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Kamalia Layal
Faculty of Medicine, University of Bangka Belitung, Bangka Belitung, Indonesia
Aisyah Anggun H
Faculty of Medicine, University of Sriwijaya, Palembang, Indonesia
Nadya Salsabillah
Faculty of Medicine, University of Sriwijaya, Palembang, Indonesia
Syarinta Adenina
Department of Pharmacology, Universitas Sriwijaya Palembang, Indonesia

Abstract

Cancer is a type of chronic disease which is the main cause of death in the world with 19.3 million new cases in 2020. Current cancer treatment includes surgery, chemotherapy, radiotherapy, hormone therapy, antiangiogenesis inhibitors, stem cell therapy, and others. Long-term cancer treatment can cause other health problems, so alternative anti-cancer therapy with the fewest side effects is needed. One natural ingredient that is known to prevent and act as anti-cancer therapy is Zingiber officinale. Zingiber officinale contains gingerol which functions as an anti-oxidant, anti-inflammatory, anti-bacterial, anti-cancer, anti-tumor and anti-mutagenic. The anticancer effects of gingerol are known to be effective in cancers of the liver, stomach, mouth, prostate, breast and ovaries. This literature aims to delve deeper into the role of gingerol as an anti-cancer compound. The strategy employed in the article search involved using electronic databases such as Google Scholar and PubMed. Keywords utilized included "cancer," "red ginger," "gingerol," "Zingiber officinale," and "anticancer." The articles selected were those published within the last 10 years. The study results indicate that gingerol is beneficial in oral, breast, lung, colorectal, cervical, and prostate cancers. The mechanism of action of gingerol involves pathways such as the PI3K/AKT, JAK/STAT, apoptosis, and ROS proliferation pathways. Gingerol is known to be effective as an anti-cancer agent and has the potential to become one of the alternative anti-cancer treatments.

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How to Cite
1.
Layal K, Anggun H A, Salsabillah N, Adenina S. THE POTENTIAL OF GINGEROL ACTIVE COMPOUNDS IN ZINGIBER OFFICINALE AS ANTI-CANCER AGENTS. International J. of Islamic and Complementary Medicine [Internet]. 2024 Oct. 1 [cited 2024 Dec. 21];5(2):122-7. Available from: https://islamicmedicine.or.id/index.php/ijim/article/view/83

References

  1. Hanggoro Putro DU, Ike Darmayanti AR, Tandiola R, Aulawi K. Pengendalian Infeksi pada Pasien Kanker: Literature Review. J Kesehat Vokasional. 2023;8(1):46.
  2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.
  3. WHO. Indonesia. Cancer Ctry Profile 2020. 2020;
  4. Abbas Z, Rehman S. An Overview of Cancer Treatment Modalities Chapter. In: Neoplasm. 2016. p. 279–96.
  5. Harun HM, Jannah N, Idawati, Ahmad ZF. Evaluasi pengobatan radioterapi pada pasien kanker. J Syifa Sci Clin Res [Internet]. 2022;4(3):662–70. Available from: https://ejurnal.ung.ac.id/index.php/jsscr/article/view/15794
  6. Rafli R, Abdullah D, Sinulingga BY. Gambaran Efek Samping dan Terapi Suportif Pasien Kanker Payudara Pasca Kemoterapi CAF di RSUP M.Djamil Padang. Baiturrahmah Med J. 2021;1(1):8–13.
  7. Zivarpour P, Nikkhah E, Maleki Dana P, Asemi Z, Hallajzadeh J. Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer. J Ovarian Res. 2021;14(1):1–13.
  8. de Lima RMT, dos Reis AC, de Menezes AAPM, Santos JV de O, Filho JWG de O, Ferreira JR de O, et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review. Phyther Res. 2018;32(10):1885–907.
  9. Novitasari R, Harsadi P, Hasbi M. Klasifikasi Jenis Jahe Berdasarkan Ciri Statistik Orde Satu Dari Warna Rimpang. J Inform Upgris. 2022;8(1).
  10. SARI D, NASUHA A. Kandungan Zat Gizi, Fitokimia, dan Aktivitas Farmakologis pada Jahe (Zingiber officinale Rosc.): Review. Trop Biosci J Biol Sci. 2021;1(2):11–8.
  11. Rukhayyah KK, Kawareng AT, Sastyarina Y. Studi Literatur: Uji Aktivitas Antioksidan Ekstrak Jahe Merah (Zingiber officinale var. Rubrum) Menggunakan Metode 2,2- diphenyl-1-picrylhydrazyl (DPPH). Proceeding Mulawarman Pharm Conf [Internet]. 2021;(April 2021):135–8. Available from: file:///C:/Users/ASUS/Downloads/R+MPC+15+Khusnul+Khatimah+R.pdf
  12. Srikandi S, Humaeroh M, Sutamihardja R. Kandungan Gingerol Dan Shogaol Dari Ekstrak Jahe Merah (Zingiber Officinale Roscoe) Dengan Metode Maserasi Bertingkat. al-Kimiya. 2020;7(2):75–81.
  13. Siregar PNB, Pedha KIT, Resmianto KFW, Chandra N, Maharani VN, Riswanto FDO. Review: Kandungan Kimia Jahe Merah (Zingiber officinale var. Rubrum) dan Pembuktian In Silico sebagai Inhibitor SARS-CoV-2. J Pharmascience. 2022;9(2):185.
  14. Zhang H, Kim E, Yi J, Hai H, Kim H, Park S, et al. [6]-gingerol suppresses oral cancer cell growth by inducing the activation of AMPK and suppressing the AKT/mTOR signaling pathway. In Vivo (Brooklyn). 2021;35(6):3193–201.
  15. Smolarz B, Zadrożna Nowak A, Romanowicz H. Breast Cancer—Epidemiology, Classification, Pathogenesis and Treatment (Review of Literature). Cancers (Basel). 2022;14(10):1–27.
  16. Ediriweera MK, Moon JY, Nguyen YTK, Cho SK. 10-Gingerol targets lipid rafts associated PI3K/Akt signaling in radio-resistant triple negative breast cancer cells. Molecules. 2020;25(14):1–13.
  17. Kang DY, Park S, Song KS, Bae SW, Lee JS, Jang KJ, et al. Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells. Cells. 2023;12(22):1–17.
  18. Salama AF, El-Far AH, Anbar EA, El-Naggar SA, Elshazli RM, Elmetwalli A. Gingerol and/or sorafenib attenuates the DAB-induced HCC and hepatic portal vein dilatation via ATG4/CASP3 and COIIV/COX-2/NF-κB expression. Med Oncol [Internet]. 2024;41(2):1–16. Available from: https://doi.org/10.1007/s12032-023-02284-3
  19. Hu SM, Yao XH, Hao YH, Pan AH, Zhou XW. 8-Gingerol regulates colorectal cancer cell proliferation and migration through the EGFR/STAT/ERK pathway. Int J Oncol. 2020;56(1):390–7.
  20. Liu CM, An L, Wu Z, Ouyang AJ, Su M, Shao Z, et al. 6-Gingerol suppresses cell viability, migration and invasion via inhibiting EMT, and inducing autophagy and ferroptosis in LPS-stimulated and LPS-unstimulated prostate cancer cells. Oncol Lett. 2022;23(6):1–11.