EXPLORING THE PROPHET MUHAMMAD'S (PBUH) RECOMMENDATION OF KALONJI AND ITS RELEVANCE IN MODERN DISEASE MANAGEMENT: A COMPREHENSIVE REVIEW

##plugins.themes.academic_pro.article.sidebar##

Published Jan 30, 2025
https://doi.org/10.55116/IJICM.V5I2.84
Download
PDF
Statistic
Vol. 6 No. 1 (2025): International Journal of Islamic and Complementary Medicine

##plugins.themes.academic_pro.article.main##

Md Tauhid Alam
PG Scholars Department of Kulliyat, Govt. Tibbi College and Hospital, Patna, India
Md. Tanwir Alam
Assistant Professor Department of Kulliyat, Govt. Tibbi College and Hospital, Patna, India
Jamal Akhtar
Associate Professor Department of Kulliyat, Govt. Tibbi College and Hospital, Patna, India
Sultana Anjum
Medical Officer, Primary Health Centre Maner, Patna, Government of Bihar, India

Abstract

The seed of Nigella sativa Linn., known by various names like Small Black Seed, Black Cumin, and Kalonji, has a rich history in treating diverse ailments, as lauded by Prophet Mohammad (PBUH) for its healing properties against numerous diseases, except death, in Islamic and Arabic traditions. Rich in volatile oils, fixed oils, tannins, proteins, and essential amino acids, Kalonji finds extensive use in Unani medicine for conditions ranging from joint pain and indigestion to asthma, diabetes, and even cancer. This review synthesizes current literature to explore Kalonji's therapeutic potential, emphasizing its historical significance and relevance in modern disease management. By elucidating its multifaceted applications, from traditional remedies to contemporary pharmacology, the review contributes to a comprehensive understanding of Kalonji's role in healthcare today.

##plugins.themes.academic_pro.article.details##

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

How to Cite
1.
Md Tauhid Alam, Alam MT, Akhtar J, Anjum S. EXPLORING THE PROPHET MUHAMMAD’S (PBUH) RECOMMENDATION OF KALONJI AND ITS RELEVANCE IN MODERN DISEASE MANAGEMENT: A COMPREHENSIVE REVIEW. International J. of Islamic and Complementary Medicine [Internet]. 2025 Jan. 30 [cited 2025 Apr. 24];6(1):1-7. Available from: https://islamicmedicine.or.id/index.php/ijim/article/view/84

References

  1. References: -
  2. Ibn Majah, Book 31, Hadith 3446.
  3. Sahih Bukhari, Book 71, Hadith 592.
  4. Sahih Muslim, Book 26, Hadith 5489.
  5. Cheikh-Rouhou, S., et al. (2007). Nigella sativa L.: uses in traditional and contemporary medicine - review of the state of the art. Critical Reviews in Food Science and Nutrition, 47(4), 237- 253.
  6. Ahmad, A., et al. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337-352.
  7. Butt, M. S., et al. (2010). Nigella sativa: reduces the risk of various maladies. Critical Reviews in Food Science and Nutrition, 50(7), 654-665.
  8. Ahmad, A., et al. (2018). Thymoquinone (TQ) as a potential therapeutic agent for cancer: Evidence from preclinical studies. Frontiers in Pharmacology, 9, 1439.
  9. Kaatabi, H., et al. (2015). The immunomodulatory and anti-inflammatory role of thymoquinone. Cardiovascular & Hematological Agents in Medicinal Chemistry, 13(1), 2-6.
  10. Randhawa, M. A., & Alghamdi, M. S. (2018). Anticancer activity of Nigella sativa (black seed) - a review. American Journal of Chinese Medicine, 46(08), 1581-1596.
  11. Heshmati, J., & Namazi, N. (2018). Effect of Nigella sativa on metabolic syndrome: A review. Journal of Endocrinological Investigation, 41(11), 1275-1281.
  12. Keyhanmanesh, R., et al. (2018). The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs. Journal of Ethnopharmacology, 224, 165-172.
  13. Meziti, H., et al. (2018). Nigella sativa: An integrated treatment approach for rheumatoid arthritis and diabetes. Advances in Pharmacological Sciences, 2018, 1-14.
  14. Boskabady, M. H., et al. (2016). The impact of Nigella sativa L. and its constituents on respiratory and allergic disorders: A review. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 15(1), 9-23.
  15. Salem, M. L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International Immunopharmacology, 5(13-14), 1749-1770.
  16. Aljabre, S. H., et al. (2015). Nigella sativa as a potential anti-osteoporosis agent in senile osteoporosis. Asian Pacific Journal of Tropical Medicine, 8(4), 270-276.
  17. Farooqui, T., et al. (2018). Neuroprotective effect of thymoquinone, a bioactive component of Nigella sativa, in a model of stroke. Neurochemistry International, 112, 25-33.
  18. Ahmad MF, Ahmad FA, Ashraf SA, Saad HH, Wahab S, Khan MS. Nigella sativa (black seed): A comprehensive review on bioactive compounds and health benefits. J Drug Deliv Ther. 2020; 10(3):237-246.
  19. Woo, C. C., et al. (2011). Nigella sativa: Towards a better understanding of its anticancer properties. Integrative Cancer Therapies, 10(4), 337-346.
  20. Rooney, S., & Ryan, M. F. (2005). Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Research, 25(3B), 2199-2204.
  21. Tavakkoli, A., et al. (2017). Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone. Journal of Pharmacopuncture, 20(3), 179-193.
  22. Gholamnezhad, Z., et al. (2016). Nigella sativa L. (Black cumin): A promising natural remedy for wide range of illnesses. Evidence-Based Complementary and Alternative Medicine, 2016, 1-16.
  23. Goyal, S. N., et al. (2016). Protective effects of thymoquinone against experimental ischemic stroke: In silico, in vitro, and in vivo studies. Neurotoxicity Research, 29(2), 275-293.
  24. Shaterzadeh-Yazdi, H., et al. (2016). The potential effect of hydro-alcoholic extract of Nigella sativa seed on reproductive system in male rat. Iranian Journal of Reproductive Medicine, 14(12), 779-786.
  25. Keshri G, Singh M.M, Lakshmi, V., Kamboj, VP; (1995) “Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats”. Indian J Physiol Pharm. 39(1):59-62.
  26. Hkm. Md. Tariq; “Kalonji ke kamalaat”. Farid Book Depot, New Delhi. Pp. 10-90.
  27. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003; 17(4):299-305.
  28. Store CB, Menu VD, Menu S. Black seed (Nigella sativa).
  29. Love LW. Black seed (Nigella sativa).
  30. Zaoui A, Cherrah Y, Mahassini N, et al. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002; 9(1):69–74.
  31. Kalus U, Pruss A, Bystron J, et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003; 17(10):1209–1214.
  32. Kaseb AO, Selim AHA. Kalonji (Thymoquinone). In Molecular Targets And Therapeutic Uses Of Spices: Modern Uses for Ancient Medicine. 2009:257–280.
  33. Mathur ML, Gaur J, Sharma R, et al. Antidiabetic properties of a spice plant Nigella sativa. Journal of Endocrinology and Metabolism. 2011; 1(1):1–8.