PRESCRIPTION PROFILE OF ANTIHYPERTENSIVE DRUGS IN PREECLAMPSIA PATIENTS AT KIRANA HOSPITAL

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Eziah Ika Lubada
Selly Septi Fandinata
Silvina Sita Alfiana
Mercyska Suryandari
Andik Isdianto

Abstract

Preeclampsia is a complication of pregnancy with symptoms of hypertension ≥ 140/90 mmHg and proteinuria ≥ 0.3 grams/24 hours or 30 mg/dl (+1 dipstick) arising after more than 20 weeks of gestation in previously normotensive pregnant women. Maternal deaths in Indonesia in 2021 related to hypertension in pregnancy reached 1077 cases (Source: Directorate General of Public Health, Ministry of Health, 2021). Pharmacological therapy intervention, antihypertensive treatment is also needed in addition to maintaining a healthy lifestyle. The purpose of the study was to determine the description of pharmacological therapy including the pharmacological class of drugs, drug names, drug doses, rules of use, and types of antihypertensive drug therapy (single / combination) in patients with preeclampsia. This type of descriptive observational research is retrospective with total sampling obtained from medical records and patient prescriptions. The results of this study were the incidence of preeclampsia aged 35 years and over by 21 patients (36%) and the most common diagnosis was mild preeclampsia by 38 samples (66%). The use of nifedipine which is included in the CCB (Calcium Channel Blocker) group was 42 respondents (72%). Meanwhile, the use of methyldopa which is included in the central sympatholytic group was 17 respondents (28%). In the single therapy type study, 59 prescriptions (100%) used nifedipine or methyldopa. Pregnant women are encouraged to routinely conduct antenatal care checks at the hospital every month.

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Author Biographies

Eziah Ika Lubada, Akademi Farmasi Surabaya

D-III Pharmacy Study Program, Akademi Farmasi Surabaya, Surabaya, Indonesia

Selly Septi Fandinata, Akademi Farmasi Surabaya

D-III Pharmacy Study Program, Akademi Farmasi Surabaya, Surabaya, Indonesia

Silvina Sita Alfiana, Akademi Farmasi Surabaya

D-III Pharmacy Study Program, Akademi Farmasi Surabaya, Surabaya, Indonesia

Mercyska Suryandari, Akademi Farmasi Surabaya

D-III Pharmacy Study Program, Akademi Farmasi Surabaya, Surabaya, Indonesia

Andik Isdianto, Universitas Brawijaya

Universitas Brawijaya

How to Cite
1.
Lubada EI, Fandinata SS, Alfiana SS, Suryandari M, Isdianto A. PRESCRIPTION PROFILE OF ANTIHYPERTENSIVE DRUGS IN PREECLAMPSIA PATIENTS AT KIRANA HOSPITAL. International J. of Islamic and Complementary Medicine [Internet]. 2024 Jul. 27 [cited 2024 Dec. 9];5(1):71-6. Available from: https://islamicmedicine.or.id/index.php/ijim/article/view/87

References

  1. Rosyidah R. Buku Ajar Mata Kuliah Obstetri Pathologi (Pathologi Dalam Kehamilan). Buku Ajar Mata Kuliah Obstetri Pathologi (Pathologi Dalam Kehamilan). 2019.
  2. Departemen Kesehatan. Pharmaceutical Care Untuk Penyakit Hipertensi. Jakarta: Direktorat Bina Farmasi Komunitas dan Klinik DITJEN Bina Kefarmasian dan Alat Kesehatan Departemen Kesehatan Republik Indonesia; 2006.
  3. Anas M, Marlina U. Penggunaan Nitrovasodilator Sebagai Donor Oksida Nitrik Pada Preeklamsia. Proceeding Annual Meeting APKKM Ke 6 Surabaya [Internet]. 2018;(April):1–27. Available from: http://journal.um-surabaya.ac.id/index.php/Pro/search/search?simpleQuery=anas&searchField=query
  4. Putri D, Mahendra AN, Indrayanti AW, Wirata G. Profil pemberian nifedipine kombinasi metildopa dan MgSO4 pada pasien pre-eklamsi berat di Rumah Sakit Daerah Mangusada Badung. Intisari Sains Medis. 2020;11(3):1222–9.
  5. Awaludin A, Rahayu C, Zakiyah N. Penggunaan Anti-Hipertensi Sebagai Terapi Untuk Hipertensi Selama Kehamilan : Telaah Pustaka Sistematik. Journal of Pharmacopolium. 2022;4(3):105–22.
  6. Rahmawati RD. Gambaran Penggunaan Methyldopa Pada Ibu Hamil Dengan Pre-Eklampsi Di Rsu Santa Maria Pemalang. Politeknik Harapan Bersama. 2020.
  7. Easterling T, Mundle S, Bracken H, Parvekar S, Mool S, Magee LA, et al. Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. Lancet (London, England) [Internet]. 2019;394(10203):1011. Available from: /pmc/articles/PMC6857437/
  8. Akbar MI, Rodiani R, Putri GT. Terapi farmakologis preeklampsia pada ibu hamil. Jurnal Kesehatan dan Agromedicine [Internet]. 2021;8:7655–800. Available from: https://juke.kedokteran.unila.ac.id/index.php/agro/article/view/3064#:~:text=Penatalaksanaan preeklampsia dilakukan secara n
  9. Soenarta AA, Rahajoe AU, Roebiono PS, Lukito AA, Sarvasti D, Anggrahini DD. Panduan Tata Laksana Penyakit Kardiovaskular Pada Kehamilan. Jakarta: Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI); 2021. 1–127 p.
  10. Karmelita DM. Efektivitas Nipedipin Sebagai Tokolitik Dalam Persalinan Prematur. Jurnal Kedokteran STM (Sains dan Teknologi Medik). 2020;3(1):1–10.
  11. Komalasari PN. Pola Peresepan Obat Antihipertensi Pada Ibu Hamil Di Rumah Sakit Dan Anak Pala Raya Mejasem. Politeknik Harapan Bersama. Politeknik Harapan Bersama Tegal; 2019.