LITERATURE REVIEW THE ROLE OF ACUPUNCTURE IN THE MANAGEMENT OF PERIPHERAL NEUROPATHY
##plugins.themes.academic_pro.article.main##
Abstract
Peripheral neuropathy (PN) is a condition characterized by damage to the peripheral nervous system, resulting in symptoms such as pain, numbness, and weakness in the hands and feet. The most common causes include diabetes, thyroid disorders, vitamin B12 deficiency, alcohol abuse, chemotherapy, and human immunodeficiency virus (HIV) infection. Despite the availability of various treatments, neurological disorders remain a significant therapeutic challenge. The therapeutic effects of acupuncture are attributed to several mechanisms, including stimulation of nerve fibers, restoration of blood flow, release of neurotransmitters and hormones, modulation of the autonomic nervous system, anti-inflammatory effects, and increased neuroplasticity. These mechanisms collectively contribute to the relief of symptoms associated with peripheral neuropathy. Evidence suggests that acupuncture is beneficial in treating peripheral neuropathy. Studies have shown that acupuncture can improve nerve conduction study parameters in sensory and motor nerves, reduce neuropathic pain, and improve overall nerve function. Certain acupuncture points such as ST-36, GB-34, SP-3, SP-8, and BI-56 have been identified as particularly effective in managing symptoms of peripheral neuropathy. Although more rigorous studies are needed to fully characterize the effects of acupuncture on peripheral neuropathy, the available evidence supports its use as a complementary therapy. Standardized acupuncture protocols that combine anatomical correlation with peripheral nerves and traditional approaches to neuropathic pain management appear to be effective. Further studies with larger sample sizes and randomized comparisons to sham acupuncture will help establish acupuncture as a guideline for treating peripheral neuropathy. This review outlines the potential of acupuncture as a complementary therapy in the management of peripheral neuropathy.
##plugins.themes.academic_pro.article.details##
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
- Hammi C, Yeung B. Neuropathy. [Updated 2022 Oct 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542220/
- Dimitrova A, Murchison C, Oken B. Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis. J Altern Complement Med. 2017 Mar;23(3):164-179. doi: 10.1089/acm.2016.0155. Epub 2017 Jan 23. PMID: 28112552; PMCID: PMC5359694
- Castelli G, Desai KM, Cantone RE. Peripheral Neuropathy: Evaluation and Differential Diagnosis. Am Fam Physician. 2020 Dec 15;102(12):732-739. PMID: 33320513.
- Lehmann, H.C., Wunderlich, G., Fink, G.R. et al. Diagnosis of peripheral neuropathy. Neurol. Res. Pract. 2, 20 (2020). https://doi.org/10.1186/s42466-020-00064-2
- Maher R Khdour, Treatment of diabetic peripheral neuropathy: a review, Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, July 2020, Pages 863–872, https://doi.org/10.1111/jphp.13241
- Dimitrova A. Introducing a Standardized Acupuncture Protocol for Peripheral Neuropathy: A Case Series. Med Acupunct. 2017 Dec 1;29(6):352-365. doi: 10.1089/acu.2017.1242. PMID: 29279730; PMCID: PMC5733739.
- Zhu J, Li J, Yang L, Liu S. Acupuncture, from the ancient to the current. Anat Rec (Hoboken). 2021 Nov;304(11):2365-2371. doi: 10.1002/ar.24625. Epub 2021 Apr 6. PMID: 33825344.
- Yang Y, Rao C, Yin T, Wang S, Shi H, Yan X, Zhang L, Meng X, Gu W, Du Y, Hong F. Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system. Front Cell Neurosci. 2023 Oct 24;17:1253438. doi: 10.3389/fncel.2023.1253438. PMID: 37941605; PMCID: PMC10627933.
- Cho E, Kim W. Effect of Acupuncture on Diabetic Neuropathy: A Narrative Review. International Journal of Molecular Sciences. 2021; 22(16):8575. https://doi.org/10.3390/ijms22168575
- Jin Y, Wang Y, Zhang J, Xiao X, Zhang Q. Efficacy and Safety of Acupuncture against Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2020 Nov 9;2020:8875433. doi: 10.1155/2020/8875433. PMID: 33224260; PMCID: PMC7669337.
- Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-418. PMID: 31658313.
- Zhuang Y, Xing JJ, Li J, Zeng BY, Liang FR. History of acupuncture research. Int Rev Neurobiol. 2013;111:1-23. doi: 10.1016/B978-0-12-411545-3.00001-8. PMID: 24215915.
- Lim C, Park S, Sun S, Lee K. Research on Korean Pharmacopuncture in South Korea since 2007. J Pharmacopuncture. 2014 Dec;17(4):15-21. doi: 10.3831/KPI.2014.17.032. PMID: 25780715; PMCID: PMC4332009.
- Kwon, S., Lee, J. W., & Kim, S. (2018, September 27). An Overview of Electroacupuncture Research Trend in Korea. Korean Journal of Acupuncture. Society for Meridian and Acupoint. https://doi.org/10.14406/acu.2018.018
- Mehta P, Dhapte V, Kadam S, Dhapte V. Contemporary acupressure therapy: Adroit cure for painless recovery of therapeutic ailments. J Tradit Complement Med. 2016 Jul 22;7(2):251-263. doi: 10.1016/j.jtcme.2016.06.004. PMID: 28417094; PMCID: PMC5388088.
- Khosrawi S, Moghtaderi A, Haghighat S. Acupuncture in treatment of carpal tunnel syndrome: A randomized controlled trial study. J Res Med Sci. 2012 Jan;17(1):1-7. PMID: 23248650; PMCID: PMC3523426.
- Jeon E, Kwon H, Shin I, Kang S, Shon H. Effect of Acupuncture on Diabetic Peripheral Neuropathy: An Uncontrolled Preliminary Study from Korea. Acupuncture in Medicine. 2014;32(4):350-352. doi:10.1136/acupmed-2013-010479
- Hoerder S, Habermann IV, Hahn K, Meyer-Hamme G, Ortiz M, Grabowska W, Roll S, Willich SN, Schroeder S, Brinkhaus B, Dietzel J. Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial. World J Diabetes. 2023 Dec 15;14(12):1813-1823. doi: 10.4239/wjd.v14.i12.1813. PMID: 38222786; PMCID: PMC10784801.
- Chien T-J, Liu C-Y, Fang C-J, Kuo C-Y. The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-Analysis. Integrative Cancer Therapies. 2019;18. doi:10.1177/1534735419886662
- Lin JG, Kotha P, Chen YH. Understandings of acupuncture application and mechanisms. Am J Transl Res. 2022 Mar 15;14(3):1469-1481. PMID: 35422904; PMCID: PMC8991130.